Pro-Tumor Inflammation (PTI) is one of the drivers of tumor growth and suppression of immune response1,2

 

Processes occur creating a tumor microenvironment conducive to PTI1,2:

An image illustrating how Pro-Tumor Inflammation (PTI) is one of the drivers of tumor growth and suppression of immune response An image illustrating how Pro-Tumor Inflammation (PTI) is one of the drivers of tumor growth and suppression of immune response

 

  • PTI can promote the survival, growth, progression, and metastasis of certain cancers1,3,4

  • There is preliminary evidence that PTI is associated with NSCLC5,6

Find out more about a potential key driver of PTI7



NSCLC, non-small cell lung cancer.

 

References:

1. Grivennikov SI, Greten FR, Karin M. Cell. 2010;140(6):883-899.
2. Greten FR, Grivennikov SI. Immunity. 2019;51(1):27-41.
3. Lu H, Ouyang W, Huang C. Mol Cancer Res. 2006;4(4):221-233.
4. Qian BZ, Pollard JW. Cell. 2010;141(1):39-51.
5. Yano S, Nokihara H, Yamamoto A, et al. Cancer Sci. 2003;94(3):244-252.
6. Ridker PM, MacFadyen JG, Thuren T, et al. Lancet. 2017;390(10105):1833-1842.
7. Carmi Y, Doton S, Rider P, et al. J Immunol. 2013;190(7):3500-3509. 

  

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