What is Pro-Tumor Inflammation and its role in cancer?1

Early tumor growth and proliferation may be driven by Pro-Tumor Inflammation (PTI) and other factors.2 PTI is a type of unregulated inflammation that promotes tumor growth.3-6

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1. Hanahan D. Cancer Discov. 2022;12(1):31-46.
2. Millares L, Barreiro E, Cortes R, et al. Lung Cancer. 2018;122:124-130.
3. Grivennikov SI, Greten FR, Karin M. Cell. 2010;140(6):883-889.
4. Greten FR, Grivennikov SI. Immunity. 2019;51(1):27-41.
5. Fleit HB. Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. 2014:300-314.
6. Lu H, Ouyang W, Huang C. Mol Cancer Res. 2006;4(4):221-233.