Pro-Tumor Inflammation (PTI) is one of the drivers of tumor survival, growth, and progression. IL-1β plays a key role in PTI.1,2
Multiple other cell types and cytokines are also implicated in PTI, including other interleukins, TNF-α, and macrophages.3
PTI is one of the drivers of tumor growth and suppression of immune response3
IL-1β plays a key role in PTI2
TNF-α, tumor necrosis factor alpha.
1. Chaudhry SI, Hooper S, Nye E, Williamson P, Harrington K, Sahai E. Oncogene. 2013;32(6):747-758.
2. Carmi Y, Doton S, Rider P, et al. J Immunol. 2013;190(7):3500-3509.
3. Grivennikov SI, Greten FR, Karin M. Cell. 2010;140(6):883-899.